Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA and other rheumatologist diseases. © 2018 UnitedHealthcare Services, Inc. 3 Authorization will be issued for 12 months. 2. Reauthorization a. Humira will be approved based on both of the following. Adalimumab, sold under the brand name Humira among others, is a medication used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriasis, hidradenitis suppurativa, uveitis, and juvenile idiopathic arthritis. Learn about Humira (Adalimumab Injection Solution for Subcutaneous Administration) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. Humira has an important use in children. Humira, and the biosimilars Amjevita and Cyltezo are FDA-approved for Juvenile Idiopathic Arthritis (JIA), also known as Juvenile Rheumatoid Arthritis, the most common form of arthritis in kids under 17. Find more information on HUMIRA (adalimumab) to learn if it may be the right treatment for your child with moderate to severe Crohn’s disease. Rheumatoid Arthritis: HUMIRA is indicated, alone or in combination with methotrexate or other non-biologic DMARDs, for reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in adult patients with moderately to severely active rheumatoid arthritis. Humira (adalimumab) is a biologic medicine that helps the pain and swelling of arthritis. It works by blocking TNF (Tumor Necrosis Factor), a type of signalling protein (called a cytokine), that is involved in systemic inflammation. HUMIRA PI Version 46 Clean Copy 29 October 2018 Page 2 of 88 4 CLINICAL PARTICULARS 4.1 Therapeutic indications Rheumatoid Arthritis Humira is indicated for reducing signs and symptoms, as well as inhibiting the progression of structural Humira (Adalimumab) is an injection given to patients who suffer from various forms of inflammatory conditions which may include rheumatoid arthritis, Crohn’s Disease, juvenile idiopathic arthritis, ankylosing spondylitis (an inflammatory disease that mostly affects the lower back) and plaque psoriasis.